Effect of POSTbiotics Supplementation on Microbiome in OBese Children: the POST-OB Study
Status:
Recruiting
Trial end date:
2021-01-07
Target enrollment:
Participant gender:
Summary
This study evaluates the possible effect of postbiotics supplementation, combined with
interventions aimed at improving diet and lifestyle, on gut microbiota composition and
metabolite production. It also wants to determine whether postbiotics supplementation,
combined with interventions to improve diet and lifestyle, reduces adverse metabolic
consequences together with their co-morbidities.
All participants will follow a behaviour (promotion of physical activity) and dietary
treatment according to Italian dietary guidelines for childhood obesity.
Postbiotics and vitamin D3 will be given orally for four months; patients will be evaluated
four months after supplementation and diet-lifestyle intervention and four months after the
end of supplementation and after the alone diet-lifestyle intervention with blood testing and
echosonography of the liver.