Effect of Oxytocin Antagonists on Implantation Success Rates of Frozen-thawed Embryo Transfer
Status:
Recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
Uterine contraction has a negative impact on implantation and pregnancy rates. Inhibition of
oxytocin receptors decreases uterine contraction frequency both on pregnant and non-pregnant
women. Atosiban has been studied as an oxytocin antagonist to decrease uterine contraction
frequency in order to increase implantation and pregnancy rates in assisted reproduction.
Previous studies have studied 37,5mg total dose which was used both before and during embryo
transfer, and found atosiban to be effective in increasing implantation and pregnancy rates.
We aim to use a single dose of 6,75mg atosiban before embryo transfer, in order to decrease
the dose and cost and possibly introduce a simpler protocol. Our study will also be the first
randomized clinical study which investigates the effect of atosiban on frozen-thawed embryo
transfer cycles.