Effect of Oral Steroids on Skin Outcomes in Atopic Dermatitis
Status:
Terminated
Trial end date:
2018-08-08
Target enrollment:
Participant gender:
Summary
Atopic Dermatitis (AD), also known as eczema, is a common skin disease characterized by itchy
lesions. The prevalence of AD has increased over the past few decades, with 15-30% of
children and 2-10% of adults being affected. The lesions of atopic dermatitis patients are
very inflamed, with an increased number of inflammatory cells in the skin. The first line
treatment for AD is steroids, which reduce inflammation in the skin. There are several ways
to measure if the treatment is effective, including clinical and cellular. We are proposing
that a controlled skin allergen challenge will be an effective way to measure the effect of
steroid at a cellular level through the measurement of inflammatory cells in the late
cutaneous response. This will be examined using a placebo-controlled trial.