Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea

• Status: Not yet recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Children OSA exhibit varying responses to opioids. It is unknown if the degree of intermittent hypoxemia results in different opioid sensitivity

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baylor College of Medicine
• Treatments: Fentanyl

Criteria

Inclusion Criteria:

• Patients undergoing tonsillectomy or adenotonsillectomy at Texas Childrens Hospital main campus.

• Ages 2 to up to 8 years

• Preoperative sleep study demonstrating obstructive sleep apnea

• Intubation without medication (e.g. no propofol prior to intubation)

• Requirement for airway instrumentation: LMA or ETT

• Inhalation induction of anesthesia

Exclusion Criteria:

• No obstructive sleep apnea

• Central sleep apnea events >1/hour

• Use of premedication

• IV induction of anesthesia

• Syndromic patients

• Known or suspected difficult airway

• Allergy to Fentanyl

• Known cardiovascular medications

• Pulmonary hypertension

• Total intravenous anesthesia required

• Parental refusal