Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Ideally, the postoperative inflammatory response is part of a well-orchestrated mechanism
that contributes to tissue healing and rapid recovery. An exaggerated uncontrolled
inflammatory response, however may lead to catabolism, tissue damage and organ failure.
Omega-3 fatty acids may provide a means to alter cellular immune responses to the benefit of
the patient. When omega-3 fatty acids are incorporated into membranes of inflammatory cells,
they trigger intracellular signalling pathways that result in a less pro-inflammatory
response. They modify gene and protein expression, modulate membrane protein activity and act
as a reservoir for bioactive molecules. They also have a strong anti-inflammatory effect by
mediating resolution of the inflammation. Furthermore, omega-3 fatty acids improve
erythrocyte function, which is vital for an adequate microcirculation, tissue oxygenation and
wound healing.
The investigators hypothesize that the perioperative administration of intravenous omega-3
fatty acids results in a rapid incorporation in immune cells and erythrocytes, thereby
reducing the postoperative inflammatory response and improving erythrocyte function in
patients undergoing colorectal surgery.