Effect of, OAT3, on the Renal Secretion of Cefotaxime
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
In the proposed study, we plan to use a genotype to phenotype strategy to study the role of
the organic anion transporter, OAT3, in drug response. More specifically we will examine the
contribution of OAT3 to the renal clearance of anionic drugs such as cefotaxime by studying
individuals with a non-functional (or poorly-functional) variant of OAT3.