Overview

Effect of Number of Meals on Metabolism After Weight Loss Surgery

Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine the effect of meal size and texture on the levels of incretin hormone, GLP-1, after Gastric Bypass Surgery (GBP). Patterns of food intake change after bariatric surgery and patients often eat multiple small low-calorie meals, a pattern that may affect blood glucose as well as incretin levels. Whether the release of GLP-1 after an oral challenge or a single liquid meal has any physiological relevance in 'real life' setting of multiple small meals diet is unclear.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Columbia University
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatments:
Acetaminophen
Criteria
Inclusion Criteria: morbidly obese individuals, BMI above 35 and less than 50 kg/m2 who
chose GBP as treatment for their obesity

- Must be able to attend all study visits at St. Luke's Roosevelt Hospital Center in
Manhattan, New York City

- Individuals with or without Type 2 Diabetes Mellitus are eligible

Exclusion Criteria:

- Patients with abnormal thyroid, renal function, known malabsorption syndrome or a
seizure disorder requiring anti epileptic therapy, and/or elevation of liver enzymes
three times above the normal limit.

- Patients with intestinal conditions such as chronic diarrhea, diverticulitis, or
irritable bowel syndrome.

- Currently pregnant or nursing.

- Known cardiovascular disease.

- Patient with current mucosal (gastrointestinal, respiratory, urogenital) or skin
(cellulitis) infection

- Any other condition which, in the opinion of the investigators, may make the candidate
unsuitable for participation in this study.

- past history of severe food allergy

- History of Type 1 Diabetes Mellitus

- Individuals taking insulin, thiazolidinedione, exenatide, or DPP-IV inhibitors