Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with
proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic
doses may decrease heartburn perception and its corresponding cortical activity measured by
magnetic resonance image. Therefore, the aim of this study was to assess the cortical
representation of heartburn in patients with NERD under treatment with nortriptyline and
placebo.
Phase:
Phase 3
Details
Lead Sponsor:
Universidade de Passo Fundo
Collaborator:
Conselho Nacional de Desenvolvimento Científico e Tecnológico