Effect of Noninvasive Ventilation on Physical Activity and Inflammation in COPD Patients
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Parallel, randomized and controlled clinical trial to evaluate the effect of 12 months of
noninvasive mechanical ventilation versus conventional treatment in hypercapnic patients with
stable COPD.
Main objective: To evaluate the effect of 12 months of noninvasive ventilation on c-reactive
protein concentration and daily physical activity in hypercapnic patients with stable COPD.
Secondary objectives: To compare the plasmatic concentration of other inflammatory biomarkers
between COPD patients with conventional treatment and wich noninvasive ventilation. To
determine the response of breathlessness, health-related quality of life and lung function to
noninvasive ventilation. To identify the COPD patients with a higher gasometric and clinic
response to noninvasive ventilation.