Our recent preclinical observations suggest that monitoring of slow electroencephalogram
(EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such
as ketamine or nitrous oxide. In this project we will carry out critical clinical research on
healthy volunteers and study the effects of nitrous oxide on EEG. Results will be used for
the design of clinical trials on depressed individuals. The project will be done in
collaboration between neuroscientists at the University of Helsinki and clinicians at the
Tampere University Hospital.