Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Background:
Mastectomy flap necrosis (MFN) is a common complication that affects recovery, reconstructive
success and aesthetic outcome. Nitroglycerin (NTG) ointment is a potent topical vasodilator
that increases local blood flow by dilating arteries and veins without altering the ratio of
pre- to post-capillary resistance. There are no studies that evaluate whether the application
of NTG ointment in patients undergoing Skin-sparing mastectomy (SSM) or nipple-sparing
mastectomy (NSM) and immediate reconstruction decreases the rate of mastectomy flap necrosis.
Objective:
To evaluate if the post-operative application of NTG ointment improve rates of MFN in
patients undergoing SSM or NSM with immediate breast reconstruction compared to patients
receiving placebo.
Hypothesis:
In patients undergoing SSM and immediate breast reconstruction there will be a decrease in
the rate of MFN in those who receive NTG ointment compared to those who receive placebo.