Effect of Nigella Sativa Seed Extract on the Blood Pressure of Elderly With Hypertension
Status:
Unknown status
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Despite of the development of new anti hypertensive agents, hypertension in elderly is still
a big health problem. Nigella sativa seed extract, derived from a small plant originating in
Middle east which can be found abundantly in Asia, has shown small antihypertensive effect in
adult. Diuretic effect of Nigella sativa is thought to be the main mechanism for the effect
but as it also shows anti-inflammatory and vasodilatory activity which are important
contributors in arterial stiffness, the main pathogenesis of hypertension in elderly, thus it
has a superior potential benefit for this population. We will conduct a randomized, double
blind, placebo-controlled trial to prove the effect of Nigella sativa seed extract in elderly
patients with hypertension. Our hypothesis is 300 mg Nigella sativa seed extract twice daily
will have anti-hypertensive effect in the blood pressure of elderly with hypertension.