Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
Our working hypothesis postulates that lipolysis is a determinant of inflammation in adipose
tissue (AT). Inhibition of lipolysis, e.g. using the oldest normolipidemic drug, nicotinic
acid, has proved valuable to combat the metabolic syndrome. Our proposal will determine
whether part of the beneficial effects of this antilipolytic compound is due to a diminution
of AT inflammation.
To this aim, the effect of nicotinic acid or placebo will be studied in male obese subjects
with or without a training program which goal is to enhance lipolysis.