Effect of Nicotine Transdermal Patch on Cognitive Function and Glycolipid Metabolism in Non-smoking Schizophrenia

• Status: Not yet recruiting
• Trial end date: 2023-02-15
• Target enrollment: 0
• Participant gender: All

Summary

Schizophrenia is a group of severe mental disorders of unknown etiology, with significant abnormalities in mental activities such as cognition, thinking, emotion, and behavior, and lead to obvious occupational and social function damage. At present, many studies have found that nicotine and cognitive function changes are related, and many studies have carried out a series of explorations for patients with schizophrenia, but there is no study on the mechanism of nicotine on cognitive function in patients with schizophrenia through changes in glycolipid metabolism, and this study intends to explore whether nicotine participates in the cognitive changes of patients with schizophrenia by regulating glycolipid metabolism, which is conducive to the in-depth study of the mechanism of cognitive function change in schizophrenia, in order to find an effective way to improve the cognitive function of schizophrenia.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sir Run Run Shaw Hospital
• Treatments: Nicotine

Criteria

Inclusion Criteria:

1. Using the DSM-V International Neuropsychiatric Jane's Interview Questionnaire (M.I.N.I.);

2. Meet the DSM-V symptom criteria for the diagnosis of schizophrenia;

3. Course of illness for 5 years and less;

4. The cumulative number of cigarettes smoked in the past is less than 100;

5. Lower secondary school or above education level;

6. Han Chinese;

7. years old≥ 18 years old;

8. Right hand;

9. Voluntarily join the study and sign an informed consent form.

Exclusion Criteria:

1. Schizophoratic disorder, bipolar disorder, mental retardation, anxiety spectrum disorder, psychotic disorder caused by drugs, alcohol and other psychoactive substances that meet the diagnostic criteria of DSM-V;

2. Have a history of cerebral organic diseases or head injury;

3. have a history of alcohol and drug dependence;

4. history of impaired consciousness for more than 5 minutes;

5. History of endocrine diseases such as thyroid dysfunction and diabetes mellitus;

6. Those who have serious abnormalities in blood picture, heart, liver and kidney function after examination;

7. pregnant and nursing women;

8. people who have been treated with electroconvulsiveness;

9. There are contraindications to magnetic resonance.