Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction

• Status: Not yet recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators evaluate the effects of intracoronary and intravenous administration of nicorandil on cardiac sympathetic nerve activity and distribution in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xuzhou Central Hospital
• Treatments: Nicorandil

Criteria

Inclusion Criteria:

1. acute ST-segment elevation myocardial infarction within 12 hours of symptom onset;

2. Age20-80,All genders

3. anterior myocardial infarction

4. The first myocardial infarction

5. The infarct-related artery(IRA) is totally occlusive

6. Blood pressure is higher than 90/60 millimeters of mercury（mmHg）

7. The time from myocardial infarction onset to reach the hospital is less than 12 hs

Exclusion Criteria:

1. kidney dysfunction (creatinine >2 mg/dl),

2. History of previous liver disease,

3. Cardiogenic shock,

4. History of myocardial infarction (MI)

5. History of coronary artery bypass grafting

6. History of allergic response to drugs

7. Severe hypovolemia