Effect of Neuromuscular Blockade and Reversal on Breathing
Status:
Completed
Trial end date:
2018-09-01
Target enrollment:
Participant gender:
Summary
In this study the investigators will assess (i) the effect of partial neuromuscular blockade
(NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to
isocapnic hypoxia and (ii) the effect over time (from TOF 0.6 to TOF 1.0) of the reversal by
sugammadex, neostigmine or placebo in healthy volunteers.
Additionally the investigators will assess the effect of partial NMB (TOF ratio 0.6) induced
by low-dose rocuronium on the ventilatory response to hypercapnia and effect over time (from
TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy
volunteers.