Effect of Nepafenac on Post-operative Macular Swelling Following Uncomplicated Cataract Surgery

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose: Study the effect of nepafenac ophthalmic suspension 0.1% to prevent post-operative cystoid macular edema following uncomplicated cataract surgery

Participants: Patients having cataract surgery at UNC who meet eligibility criteria

Procedures (methods): Patients will have pre and post-operative vision measured and optical coherence tomography (OCT) testing, also cataract density and intraoperative phacoemulsification parameters including ultrasound power and ultrasound time will be measured. Patients will be randomized into two groups. Group 1 will be treated with standard post-operative cataract management. Group 2 will be treated with standard post-operative cataract management plus topical nepafenac for one month. Post-operative macular thickness will be studied by analyzing the visual acuity and OCT measurements at two months post surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Collaborator: Research to Prevent Blindness
• Treatments: Anti-Bacterial Agents; Nepafenac

Criteria

Inclusion Criteria:

• over age 50

• having cataract surgery at UNC

Exclusion Criteria:

• medically controlled diabetes

• history of intraocular surgery

• abnormal pre-op optical coherence tomography scan

• history of ocular inflammation

• have age related macular degeneration