Effect of Nefopam on Remifentanil Induced Postoperative Hyperalgesia
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Opioids has been reported to cause hyperalgesia. Opioid induced hyperalgesia (OIH) is defined
as paradoxically lowering the threshold of pain after the exposure of opioid. Remifentanil is
a short acting opioid that is commonly used during anesthesia and surgery. However, OIH was
reported to occur after surgery when large amount of remifentanil was administered. On the
other hand, nefopam is a centrally acting, non-opioid analgesic. Nefopam has been reported to
have analgesic and anti-hyperalgesic effect.
The investigators hypothesized that nefopam administration could prevent OIH or reduce the
severity of OIH. Therefore, the objective of the study is to find out the effect of nefopam
on remifentanil induced hyperalgesia in patients undergoing laparoscopic abdominal surgery.