Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac Surgery
Status:
Recruiting
Trial end date:
2022-11-14
Target enrollment:
Participant gender:
Summary
Postoperative ileus, defined as the transient postoperative functional inhibition of
propulsive bowel activity, commonly occurs in patients after cardiac surgery and contributes
to postoperative morbidity.
Naloxegol is a peripheral opioid receptor antagonist. Recent studies showed that naloxegol is
effective in the treatment of chronic opioid-induced constipation but there is no data on its
use in the management of postoperative ileus after cardiac surgery.
The main objective of this prospective, double-blind, randomized, placebo-controlled trial is
to assess the effectiveness of the perioperative use of naloxegol in reducing the duration of
the postoperative ileus in patients undergoing cardiac surgery.