Effect of N-Acetylcysteine on Autologous Fat Graft Survival

• Status: Unknown status
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

A single-centre triple-blind study looking at the addition of NAC to tumescent solution for liposuction and fat grafting in healthy patient volunteers already undergoing bilateral breast reduction. Three-dimensional reconstructions and volumetric analysis will be performed based on CT scans at 0, 1 and 3 months and then histological analysis will be performed after fat graft explantation at 3 months to determine fat graft vascularity and quality.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Michael Bezuhly
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

1. Women

2. Desire and surgical indication for liposuction of the thigh/hip region for women already undergoing elective breast reduction surgery

3. Age 18-45 years

4. BMI of 20-30

5. ASA Class I

Exclusion Criteria:

1. Known chronic illnesses: Diabetes, HIV, renal/liver failure, metabolic disease, history of cancer or family pre-disposition of cancer, peripheral vascular disease, illness that would preclude a general anaesthetic

2. Pregnancy or planned pregnancy within 1 year

3. Contraindications to CT

4. Previous hip/thigh surgery or injury

5. Previous lower leg surgery/injury

6. Smoker

7. Breastfeeding

8. Other disease according to investigator's judgment