Overview

Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
0
Participant gender:
All
Summary
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Saskatchewan
Treatments:
Acetaminophen
Analgesics, Opioid
Anesthetics
Dexamethasone
Dexmedetomidine
Dsuvia
Gabapentin
Ketamine
Lidocaine
Magnesium Sulfate
Ondansetron
Pharmaceutical Solutions
Sevoflurane
Sufentanil
Criteria
Inclusion Criteria:

- Age > 18, American Society of Anesthesiology (ASA) class I-III patients scheduled for
elective laparoscopic/laparoscopic assisted colorectal surgery

Exclusion Criteria:

- Emergency surgery, open surgery, contraindications to laparoscopic surgery (ie.
adhesions, inability to tolerate pneumoperitoneum), American Society of Anesthesiology
(ASA) class 4, age < 18, pregnant or breastfeeding women, significant
cardiorespiratory/hepatic/renal disease, allergy to any study drugs, inability to
consent, inability to respond to pain assessments, inability to use the patient
controlled analgesia device (PCA)