Effect of Midazolam and Dexmedetomidine on Heart Function - A Randomized MRI-based Study.

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To compare the changes in heart function, induced after sedation with midazolam or dexmedetomidine, using cardiac magnetic resonance imaging (MRI).

This study is a randomized unmasked study, in which participant will be allocated by the envelop method into the dexmedetomidine (DEX) group or into the midazolam (MID) group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Masaryk Hospital Krajská zdravotní a.s.
• Treatments: Dexmedetomidine; Midazolam

Criteria

Inclusion Criteria:

• Patients who were admitted due to chest pain, in whom acute coronary syndrome, pulmonary embolism and acute aortic syndrome were ruled out

• Age ≥18 and ≤ 65 years

• No contraindication to provide cardiac MRI

• No known allergy to Midazolam or Dexmedetomidine

• Signed informed consent

• No history of heart, hepatic, renal or respiratory failure

Exclusion Criteria:

• Atrial fibrilation

• Claustrophobia

• Heart Failure

• Renal Failure

• Hepatic disease

• Respiratory insufficiency

• Fertility and lactation

• Patients who cannot cooperate or refuse to sign the consent.