Effect of Midazolam Premedication on the Satisfaction Levels of Patients After Endoscopic Submucosal Dissection
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Endoscopic submucosal dissection is commonly performed under light to moderate sedation, and
minimizing patient movement is of key importance for successful outcome. Propofol has widely
replaced benzodiazepines as sedative drug of choice, and has been reported to enhance the
quality of procedure in our past study. However, despite higher satisfaction scores of the
endoscopists and faster post-procedural recovery, patient satisfaction scores were found to
be higher in patients that received midazolam and meperidine instead of propofol and
remifentanil. This seems to be due to the anterograde amnestic effects of midazolam rather
than the quality of sedation itself. Investigator hypothesized that by premedicating the
patient with low lose midazolam before receiving sedation for ESD with propofol and fentanyl,
patient satisfaction would be enhanced without affecting endoscopic performance.