Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
This study evaluates the pathophysiological effects of a single dose Methylprednisolone
administered prior to total knee-arthroplasty (TKA). The investigators examine the effect on
thigh muscle function to evaluate the efficacy of Methylprednisolone on knee-extension
strength at discharge after TKA.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the group receiving Methylprednisolone will experience
smaller loss of knee-extension strength compared to the placebo-group, early after TKA.