Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
The study evaluates the pathophysiological effects of a single dose Methylprednisolone
administered prior to total hip-arthroplasty (THA) surgery. The investigators examine the
effect on orthostatic intolerance, orthostatic hypotension and heart rate variability (HRV)
to evaluate the efficacy of Methylprednisolone regarding blood pressure regulation and
autonomic responses after THA.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the group receiving Methylprednisolone will be less
orthostatic intolerant, experience less orthostatic hypotension and have an improved
autonomic response compared to the placebo-group, early after THA.