Effect of Methylprednisolone on Endothelial Function in Patients Undergoing Total Knee-arthroplasty
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
This study evaluates the pathophysiological effects of a single dose methylprednisolone
administered prior to total knee-arthroplasty surgery (TKA). The investigators examine the
effect on the endothelial glycocalyx shedding due to surgical trauma.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the group receiving methylprednisolone will experience
reduction in glycocalyx degradation compared to the placebo-group, early after TKA.