Effect of Methylprednisolone on Complement Activation in Patients Undergoing Total Knee-arthroplasty
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
This study evaluates the pathophysiological effects of a single dose of methylprednisolone
administered prior to total knee-arthroplasty surgery. The investigators examine the effect
on complement activation.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the group receiving methylprednisolone will experience
beneficial inhibition of the undesirable parts of the complement activation.