Effect of Methylnaltrexone on GI Transit in Healthy Volunteers
Status:
Completed
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
This is a single-center, randomized, double blind, placebo-controlled study evaluating the
effects of placebo, codeine, methylnaltrexone and codeine with methylnaltrexone on
gastrointestinal motility and colonic transit of solids in healthy human subjects.
The hypotheses are:
1. Methylnaltrexone administered subcutaneously enhances gastrointestinal motility with
acceleration of overall colonic transit, and ascending colon emptying of solids in
healthy humans.
2. Methylnaltrexone significantly accelerates colonic transit that is delayed by codeine