Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice

• Status: Unknown status
• Trial end date: 2021-01-21
• Target enrollment: 0
• Participant gender: All

Summary

Increased production of vasodilating substances such as NO plays an important role in the development of vasoplegic syndrome caused by obstructive jaundice.Methylene blue plays a role in raising blood pressure by inhibiting the vasodilator Nitric Oxide (NO)

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jiaolin Ning,MD
• Treatments: Methylene Blue

Criteria

Inclusion Criteria:

1. Age: 18~70 years old;

2. ASA grade I~III;

3. Ability to comply with research protocols;

4. Patients with obstructive jaundice: patients with total bilirubin greater than 50umol/L;

5. Voluntarily participate in the study and sign the informed consent form. -

Exclusion Criteria:

1. ASA IV~V grade;

2. women during lactation and pregnancy;

3. Patients with severe heart disease or lung disease before surgery;

4. Participating in other trials in the last 2 months;

5. Those whose mental state cannot cooperate, who suffer from mental illness, have no self-control, and cannot express clearly;

6. Those who refuse to sign the informed consent form. -