Effect of Methyldopa on MHC Class II Antigen Presentation in Type 1 Diabetes
Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
Type 1 Diabetes is an autoimmune condition in which segments of the immune system cause the
destruction of insulin producing cells in the pancreas, leaving individuals with an impaired
ability to control blood glucose levels. Currently there is no cure for Type 1 Diabetes and
the treatments involve lifelong insulin administration and careful monitoring of blood
glucose levels. Long-term complications like cardiovascular disease, nerve damage, and retina
damage, may result. Previous studies have shown that improvement in the control of blood
glucose can reduce the risks from these long-term complications. Residual insulin production,
typically within the first few years following diagnosis, helps to reduce an individual's
need to supplement insulin by injection or pump. This effect helps in maintaining the body's
ability to regulate blood glucose levels and reducing the needs of external insulin.
Methyldopa, or Aldomet, has been approved by the Food and Drug Administration and is commonly
used to treat high blood pressure. This drug has been approved for several decades and has
been shown to be safe and effective. This drug has been identified by the researcher to be
able to block the communication between two important types of immune cells; which play a
critical role in the autoimmune processes of Type 1 Diabetes. The investigators hypothesize
that Methyldopa, over a 6 week treatment period, will block this communication and possibly
slow down the destruction of insulin producing cells. The investigators hope to assess the
appropriate and safe dose to achieve this effect, along with the drug's ability to maintain
insulin production and blood glucose control.
Phase:
N/A
Details
Lead Sponsor:
University of Colorado Denver School of Medicine Barbara Davis Center