Effect of Methotrexate on Inflammatory Response in Adult Atopic Dermatitis Patients
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with pruritus.
Methotrexate can be used to treat refractory disease to conventional therapy.
It will be conducted a single arm trial with twelve adult patients with moderate to severe AD
on methotrexate for 24 weeks.
Investigators intend to evaluate the effect methotrexate on cytokines and chemokines involved
in the inflammatory response, on IgE levels, on pruritus, and on EASI and SCORAD severity
scores.
Phase:
N/A
Details
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborator:
FUNADERSP (Foundation for Research Support of the State of São Paulo)