Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk
in type 1 diabetes (T1D). The purpose of this study is to measure the effect of metformin on
insulin sensitivity, vascular function and compliance, and mitochondrial function in T1D. The
long term goal is to identify novel non-glycemic approaches to managing cardiovascular
disease risk in T1D. The results of this study may validate a novel approach to T1D treatment
that could significantly improve current management of cardiovascular disease risk in this
high risk population.
Phase:
Phase 4
Details
Lead Sponsor:
University of Colorado, Denver
Collaborators:
US Department of Veterans Affairs VA Office of Research and Development