Effect of Metformin on Non PCO Women Undergoing IVF/ICSI

• Status: Recruiting
• Trial end date: 2020-11-27
• Target enrollment: 0
• Participant gender: Female

Summary

400 Patients will be randomly assigned into two groups after informed consent from every patient.

They will be classified into 2 groups:

Group A ( involves 200 patients ) will receive metformin 850 mg twice daily along the cycle of Intra-cytoplasmic sperm injection (ICSI) Group B ( involve 200 patients) will not receive metformin. They will undergo a cycle of ICSI. Primary outcome of this trial is to detect occurrence of Ovarian Hyper-stimulation Syndrome (OHSS) , while secondary outcomes include quality & number of retrieved

follicles fertilization rate ,ongoing pregnancy rate & endometrial thickness.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Patients subjected to IVF/ICSI aged 20-35 years with long agonist protocol

• history of infertility for at least two years (either primary or secondary)

• normal TSH and prolactin

Exclusion Criteria:

• Patients who used metformin in the past 3-months before study

• having medical problems such as kidney or liver diseases

• Severe endometriosis.

• hypothalamic amenorrhea.

• Severe male factor( patients with testicular biopsy or those with azoospermia).

• Associated uterine factor.

• IVF/ ICSI for sex selection.