Effect of Metformin on Exercise-induced Lipolysis

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this study is to investigate whether metformin has inhibitory effect on exercise-induced lipolysis in subcutaneous adipose tissue in healthy lean man. Ten healthy lean mean will follow protocols consisting of 60 minutes of exercise on bicycle ergometer combined with a) orally administered metformin and b) locally administered metformin into adipose tissue and c) without metformin treatment. Microdialysis is used for assessment of metabolites in situ in subcutaneous adipose tissue.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Charles University, Czech Republic
• Treatments: Metformin

Criteria

Inclusion Criteria:

• healthy lean men, non obese, BMI 20-28 kg/m2

Exclusion Criteria:

• weight change within the 3 months before the study,

• hypertension,

• impaired fasting glucose

• diabetes

• hyperlipidemia

• drug or alcohol abuse

• smoking