Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects

• Status: Completed
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial is designed to evaluate the alteration of gut microbiome in healthy subjects after a 12-week metformin and/or probiotics administration.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
• Treatments: Metformin

Criteria

Inclusion Criteria:

1. Between 20-60 years of age.

2. Healthy subjects without known diseases.

Exclusion Criteria:

1. During pregnancy and lactation period.

2. Impaired liver function, impaired renal function, mental disease, severe infection, severe anemia, severe heart disease and neutropenia disease.

3. Use of metformin/antibiotics within 3 months.

4. Immunodeficient or use of immunosuppressive drugs.

5. Previous history of gastrointestinal surgery or diseases (such as peptic ulcer, irritable bowel syndrome, inflammatory bowel disease or other gastrointestinal disorder).

6. Medical conditions or diseases that may affect subject safety or confound study results in the opinion of the investigator.