Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
One of nicotine's effects on the body is at the level of the NMDA receptors in the brain.
Memantine is a drug that also affects NMDA receptors, making it a candidate for the treatment
of nicotine addiction. The purpose of this study is to evaluate the effectiveness of
memantine using a laboratory model of smoking relapse in nicotine dependent volunteers.
Investigators will compare the effects of memantine with bupropion, medication currently used
to facilitate smoking cessation.