Overview

Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex

Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of this study is to determine the recovery time of moderate neuromuscular blockade with sugammadex in adults pretreated with magnesium sulfate.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Universidade Federal do Rio de Janeiro
Collaborator:
Hospital Federal de Bonsucesso
Treatments:
Magnesium Sulfate
Molecular Mechanisms of Pharmacological Action
Rocuronium
Criteria
Inclusion Criteria:

- Age 18-65 years

- ASA physical status 1 or 2

- weight BMI 18.5-24.9

- otorhinolaryngological surgeries

Exclusion Criteria:

- major surgery associated with massive blood loss or fluid replacement

- any known allergy to magnesium sulphate or any other study drugs

- pregnant

- anatomical malformations expected to result in a difficult intubation;

- known or suspected neuromuscular disorders and/or significant hepatic or renal
dysfunction

- administration of any medication known to interfere with neuromuscular blocking agents
(such as anticonvulsants, aminoglycosides, calcium channel blockers and magnesium
containing medications)

- hypomagnesemia, hypermagnesemia, hypocalcemia, hypercalcemia