Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
Status:
Withdrawn
Trial end date:
2018-07-17
Target enrollment:
Participant gender:
Summary
This study will test whether longer-term suppression of adrenal function can ameliorate
androgen (male hormone) overproduction in overweight early pubertal girls with androgen
excess. The investigators hypothesize that suppression of nighttime adrenocorticotropin
hormone (ACTH) production by 12 weeks of evening oral hydrocortisone administration will
improve androgen levels in girls with adrenal androgen overproduction. Specifically, this
intervention will improve androgen levels after adrenal stimulation testing with ACTH or
ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).