Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
Status:
Completed
Trial end date:
2020-09-12
Target enrollment:
Participant gender:
Summary
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been
found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier
may decrease bone loss around implants.
PURPOSE: To compare the long term effects of autologous PRF alone, and PRF loaded with SIM on
peri-implant bone changes and implant stability in patients undergoing implant
rehabilitation.
MATERIALS AND METHODS: A randomized controlled split-mouth studyincluding 8 males between the
ages of 45-60 years. Each patient received two implants, one on each side of the arch. One
side was treated with PRF alone and the other side with PRF +Simvastatin, at the time of
Osteotomy. A cone-beam CT was used to evaluate bone changes around the insertion of implant
sites atthree, six, and twelve months postoperatively. The secondary outcome included
measuring implant stability using Ostell device at baseline and 3 months post insertion. To
compare groups at different time periods, data was examined using a two-way (ANOVA) analysis.