Effect of Lixisenatide on Postprandial Plasma Glucose Compared to Sitagliptin in Combination With Insulin Glargine
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
Primary Objective:
To demonstrate significant reduction in postprandial plasma glucose (ΔAUC0:30-4:30h) after a
standardized breakfast from baseline to Day 29.
Secondary Objectives:
To demonstrate:
- Changes from baseline to Day 29 in maximum postprandial plasma glucose excursion,
C-peptide and glucagon levels after a standardized breakfast
- Delaying gastric emptying (13C-acetic acid breath test)
- Safety and tolerability