Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial is conducted in Asia. The trial is designed to compare the effect on glycaemic control of liraglutide or glimepiride added to metformin in subjects with type 2 diabetes

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Novo Nordisk A/S
• Treatments: Glimepiride; Liraglutide; Metformin

Criteria

Inclusion Criteria:

• Type 2 diabetes

• Subjects diagnosed with type 2 diabetes and treated with one or more oral antidiabetic drugs (OADs) for the last 3 months

• HbA1c: 7.0-11.0% (both incl.) for subjects on OAD alone

• HbA1c: 7.0-10.0 % (both incl.) for subjects on OAD combination therapy

• BMI less than 45.0 kg/m^2

Exclusion Criteria:

• Treatment with insulin within the last 3 months prior to the trial

• Impaired liver or/and renal function

• Significant cardiovascular disease over the last 6 months

• Known retinopathy or maculopathy

• Recurrent major hypoglycaemia or hypoglycaemic unawareness