Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine
Status:
Completed
Trial end date:
2018-09-01
Target enrollment:
Participant gender:
Summary
The goal of this protocol is to evaluate the effect of addhing linagliptin to patients with
prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin
alone. The duration of the study will be 6 months, and it is primarily a efficacy study. Main
outcomes will be glucose levels during OGTT, insulin secretion and pancreatic beta cell
function measured by the disposition index derived from the OGTT.