Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine
decreased the incidence of postoperative nausea and vomiting (PONV). The investigators
investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the
incidence of PONV after laparoscopic hysterectomy.
METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly
divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD
group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine
(0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON
group, n=60) received the equal volume of saline. Primary outcome was the incidence of the
first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included
perioperative propofol and remifentanil consumption, postoperative fentanyl requirement,
Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.