Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab
Status:
Recruiting
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
An outstanding scientific question, that merits further investigation, is whether dilation of
intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here,
we hypothesize that experimentally-induced dilation of intracranial arteries using
intravenous infusion of levcromakalim (a potent vasodilator) induces cephalic pain with
migraine-like features in people with migraine, who prior to the infusion are administered
erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody).