Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children
Status:
Completed
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Recent studies showed that intestinal microbiota consist more than thousand bacteria, and
these microorganisms play the role as balance and continuity of the anatomical and functional
integrity gastrointestinal tract. Chronic diseases, nutritional factors, lifestyle factors
and medications including antibiotics changes the host microbiota in short or long-term
period. Antibiotics are the most commonly used drugs in pediatrics routine practice. Although
frequency and severity of side effects alter the choice of drug, mild complications may be
taken into consideration for treatment by a physician in the profit and loss balance. Our
study group (PROBAGE Working Group) have been recently showed that Lactobacillus reuteri DSM
17938 reduced the duration of diarrhea in children with acute infectious diarrhea, and are
safe and well-tolerated. In this study the investigators aim to evaluate the potential effect
of Lactobacillus reuteri DSM 17938 on the prevention of antibiotic associated diarrhea in
children.
Phase:
Phase 4
Details
Lead Sponsor:
Eskisehir Osmangazi University
Collaborators:
Acıbadem University Medical School Acıbadem University School of Medicine Bezmialem University Medical School Ege University Medical School Erzurum Regional Training & Research Hospital Fırat University Medical School Goztepe Training and Research Hospital Hacettepe University Namik Kemal University Okmeydani Training and Research Hospital Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Sisli Etfal Training & Research Hospital Sisli Hamidiye Etfal Training and Research Hospital Umraniye Education and Research Hospital Yuzuncu Yıl University