Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria

• Status: ACTIVE_NOT_RECRUITING
• Trial end date: 2026-08-01

Summary

Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria

L-carnitine is mainly obtained from foods such as red meat and milk that are limited for PKU patients due to dietary protein restriction. So, L-carnitine deficiency has been described in phenylketonuric patients

The aim of this study is to :

1. Compare level of Brain-derived neurotrophic factor in infants and children with phenylketonuria and healthy infants and children.

2. Compare level of phenylalanine and Brain-derived neurotrophic factor before and after L-carnitine supplementation in phenylketonuric patients.

3. Assess Intelligence quotient test before and after L-carnitine supplementation in phenylketonuric patients

• Phase: PHASE4

Details

• Lead Sponsor: Mansoura University
• Treatments: Carnitine