Effect of L-arginine and Glutamine on Preterm

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

effects of enteral l-arginine to decrease feeding intolerance and risk of NEC in neonates via its role as a NO precursor. Also, enteral glutamine which may play a role as an immunomodulator on preterm neonates. all these had never been studied in developing countries where sepsis and nec act as a major participant in mortality rates.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University

Criteria

Inclusion Criteria:

-Gestational age ≤34 weeks

Exclusion Criteria:

• Severe congenital anomalies.

• Congenital non-bacterial infection

• Evidence of intraventricular hemorrhage (IVH) grade ≥II on cranial ultrasound scan by day 3 of life

• Conjugated hyperbilirubinemia

• Evidence of an inborn error of metabolism

• Exchange transfusion during the study period