Effect of Knee Pain on Walking Biomechanics

• Status: Recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking. The main questions it aims to answer are:

• How does unilateral knee pain affect contralateral knee joint loading during different types of walking?

• Does movement and loading change at the hips, knees, and ankles during prolonged walking in persons with painful knee osteoarthritis?

Participants will:

• Fill out questionnaires/surveys

• Complete clinical examinations

• Walking on a treadmill under different types of walking conditions

• Receive two knee injections For comparison purposes, researchers will also enroll healthy participants.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: St. Louis University
• Treatments: Lidocaine

Criteria

Inclusion Criteria for Knee Osteoarthritis Arm:

• At least 45 years old

• Unilateral knee pain with walking that averages at least 3 out of 10 on a numeric pain rating scale

• Unilateral knee stiffness that lasts less than 30 minutes after periods of inactivity

• Unilateral symptoms on most days for at least the past 3 months

Exclusion Criteria for Knee Osteoarthritis Arm:

• History of lower body surgery

• History of lower body trauma

• Opiate use within the past 3 months

• Narcotic use within the past 3 months

• Known medical condition that affects walking mechanics, besides knee osteoarthritis

• Known medical condition that affects pain perception

• Inability to walk for 30 minutes without using an assistive device

• Body weight greater than 300 pounds

• Known allergy to adhesives

• High risk for a cardiovascular event

• Currently pregnant

• Anticoagulant use within the past 3 months

• Intraarticular knee injection within the past 3 months

• Known history of hypersensitivity to local anesthetics of the amide type

• History of lower body pain or injury, besides knee osteoarthritis, within the past 6 months

Inclusion Criteria for Healthy Arm:

• At least 45 years old

• No lower body pain or injury within the past 6 months

Exclusion Criteria for Healthy Arm:

• History of lower body surgery

• History of lower body trauma

• Opiate use within the past 3 months

• Narcotic use within the past 3 months

• Known medical condition that affects walking mechanics

• Known medical condition that affects pain perception

• Inability to walk for 30 minutes without using an assistive device

• Body weight greater than 300 pounds

• Known allergy to adhesives

• High risk for a cardiovascular event

• Currently pregnant