Overview

Effect of Ketamine (Ketalar) on Intracranial Pressure

Status:
Unknown status
Trial end date:
2007-02-01
Target enrollment:
0
Participant gender:
All
Summary
Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency situations, specifically in patients with traumatic brain injury (TBI) and with increased ICP. Based on previous clinical experience, we hypothesized that Ketamine decreases - rather than increases - ICP. Methods: Prospective, controlled, clinical trial. Children with ICP monitoring will receive a single Ketamine dose (1-1.5 mg/kg) either for increased ICP and/or before a potentially distressing activity. Hemodynamic variables, ICP and cerebral perfusion pressure (CPP) will be recorded 1 minute before and every minute for 10 minutes following Ketamine administration (Before/after design).
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Rambam Health Care Campus
Treatments:
Ketamine
Criteria
Inclusion Criteria:

- Children who have an ICP monitoring device, who either have increased ICP and/or who
should undergo a potentially distressing activity (suction, position change etc.).