Effect of Januvia on Beta Cell Function in Patients With Diabetes Mellitus
Status:
Completed
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
The study is designed to investigate the effect of 18 weeks treatment with Sitagliptin 100
mg/day on the insulin secretion capacity of beta cells.
Patients who meet the study enrollment criteria will undergo 2 experiments (see description
below); a graded hyperglycemic technique and a meal test, prior to randomization and after a
12-wk double-blind study period. The treatment effect will shed light on the magnitude of the
beta cell capacity to increase its mass and function.